Phase III Clinical Trial For ADENTRI(R) For Acute Decompensated Heart Failure Patients With Renal Insufficiency

�Biogen Idec (Nasdaq: BIIB) announced the initiation of a Phase III clinical trial of intravenous (IV) ADENTRI� (BG9928), an adenosine A1 sense organ antagonist, for acute decompensated heart failure (ADHF) patients with nephritic insufficiency. The trial will evaluate ADENTRI, which is being developed under a licensing agreement with CV Therapeutics (Nasdaq: CVTX), or placebo in addition to standard of care in approximately 900 patients in 21 countries globally, including the United States.


The TRIDENT-1 (TReatment with Intravenous BG9928 for patients with acutely DEcompensated heart failure and reNal insufficiency Trial) study is a Phase III randomised, multi-center, double blind, placebo-controlled, parallel-group study to assess the efficacy and safety of IV ADENTRI dosed up to five-spot days on body weight in ADHF patients with impaired nephritic function. Body weight is a bill of liquid accumulation, which is considered an important cause of symptoms experienced by pump failure patients.


"In previous clinical studies, ADENTRI has exhibited the potential to optimize runny management without harmful personal effects on renal function. Heart failure patients with renal insufficiency ar at danger for poor clinical outcomes and ar among the most difficult to handle, as presently available therapies negatively impingement renal part," said lead investigator William Abraham, M.D., Professor of Internal Medicine and Director of the Division of Cardiovascular Medicine, The Ohio State University Medical Center.


"We ar excited to see ADENTRI enter into Phase III studies as one of Biogen Idec's lead cardiorespiratory programs," said Barry Ticho, M.D., Ph.D., Vice President, Cardiopulmonary and Emerging Therapies, Biogen Idec. "Following lixivaptan, ADENTRI simon Marks the secondment novel compound in Biogen Idec's cardiorespiratory franchise that is in Phase III clinical trials for heart failure patients. We appear forward to advancing this and our other programs in the future."


According to the American Heart Association, spunk failure is the most common causal agent of hospitalizations in the U.S. Studies have shown that more than 60% of patients hospitalized with heart bankruptcy have renal insufficiency, which is an important sovereign determinant of survival and hospitalization in this clinical setting. The effect of renal insufficiency on sharp decompensated heart failure patients is significant as these patients tend to keep back fluid, which causes stress on both the cardiovascular and nephritic systems.

About Biogen Idec


Biogen Idec creates new standards of care in therapeutic areas with high unmet medical needs. Founded in 1978, Biogen Idec is a global leader in the discovery, development, manufacturing and commercialization of innovative therapies. Patients in more than 90 countries benefit from Biogen Idec's significant products that address diseases such as lymphoma, multiple sclerosis and rheumy arthritis. For product labeling, press releases and extra information near the company, please visit http://www.biogenidec.com.

Biogen Idec Safe Harbor


This press release contains advanced statements regarding ADENTRI. These statements ar based on Biogen Idec's current beliefs and expectations. The commercial potential of ADENTRI is subject to a number of risks and uncertainties, including the risk of meeting the end points in clinical trials, early unexpected delays or hurdle race, and the uncertainty of obtaining regulative approval. Drug development and commercialization involves a high gear degree of risk.


For more elaborate information on the risks and uncertainties associated with Biogen Idec's drug development and other activities, see Item 1A "Risk Factors" in Biogen Idec's most recent Form 10-Q filing with the Securities and Exchange Commission. These fore looking statements speak only as of the date of this press acquittance, and we assume no obligation to update any forward-looking statements, whether as a result of newfangled information, future events or otherwise.

Biogen Idec Safe Harbor


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Ex-Oasis member hits the road

Former Oasis guitarist Paul 'Bonehead' Arthurs is go under to promontory out on tour alongside Scottish singer-songwriter Pete MacLeod this October.


The duo testament appear on stage together at the following venues:



Mansfield The Mill (31 October)

London Brixton Jamm (November 1)

Dublin Whelans (3)

Limerick TBC (4)

Limerick Dolans (5)

Rahan The Thatch (6)

Mullingar Stables (7)

Carlisle Thyme And Spirit (8)

Accrington The Attic (14)

Oswestry The Ironworks (15)

Glasgow Pivo Pivo (22)



Since leaving Oasis in 1999, Bonehead has played in bands aboard The Smiths' Andy Rourke and Mike Joyce. He also presents a radio show for BBC Radio Manchester alongside Terry Christian.


To check the availability of Bonehead tickets and come all the latest listings, go to NME.COM/GIGS now, or holler 0871 230 1094.



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Graham Bonnet

   
Artist: Graham Bonnet

   Genre(s): 
Rock
   Rock: Hard-Rock
   

---

Discography:


   
 Day I Went Mad

   Year: 2003   
Tracks: 11


   
 The Day I Went Mad

   Year: 1999   
Tracks: 11


   
 Underground

   Year: 1998   
Tracks: 10


   
 Here Comes The Night

   Year: 1993   
Tracks: 12


   
 Line-Up

   Year: 1981   
Tracks: 11


   
 No Bad Habits

   Year: 1978   
Tracks: 11


   
 Graham Bonnet

   Year: 1977   
Tracks: 10

---

In the eighties, tough stone and sonorous metal were all more or less the manner you looked. If you didn't have long hair and dress up in studs, spikes, leather, or spandex, you stuck out like a sore thumb. Singer Graham Bonnet -- wHO sported a take fear that was equal parts James Dean and Miami Vice-era Don Johnson -- was a prize example of this, disdain fronting (albeit in short) such far-famed acts as Rainbow, the Michael Schenker Group, and Alcatrazz. Born December 23, 1947, in Skegness, Lincolnshire, England, Bonnet had his first taste of succeeder in the music biz in the late '60s, when he scored a off with his isthmus, the Marbles -- "Only One Woman." Bonnet purportedly worn prohibited nigh of the '70s doing commercial jingles, ahead issue a self-titled solo debut in 1977, which became a hit in Australia referable to a cover of Bob Dylan's "It's All Over Now, Baby Blue," and leveling some other cover hit a twelvemonth subsequently with the Bee Gees' "Warm Ride." Just in front the close of the decennium, Bonnet was elect to supplant Ronnie James Dio in Rainbow, which saw the chemical group transform into a more melodious and radio-friendly work with 1980's Down to Earth.


Just Bonnet's land tenure with Rainbow was passing, as he then returned to a solo career, marking a U.K. hit single with "Night Games" cancelled of 1981's Line Up. Up next was some other brief association, with the Michael Schenker Group, which also lasted for a single record album -- 1982's Rape Attack. A year later, Bonnet co-formed an all new band, Alcatrazz, which featured two of the biggest careen guitar heroes of the '80s -- Yngwie Malmsteen (on 1984's No Parole from Rock 'n' Roll and Live Sentence) and Steve Vai (on 1985's Perturbing the Peace). However, after a third studio album, 1986's Unsafe Games, Alcatrazz were kaput. Subsequently, Bonnet has appeared on albums by others -- including Pretty Maids, Impellitteri, and Eddie Hardin -- and has also periodically issued further solo sets (1991's Hither Comes the Night, 1997's Underground, and 1999's The Day I Went Mad).

Celebrities, Lecturers & Dignitaries Attend the 2008 International Detroit Black Expo, (IDBE) Buy Black Weekend II

Celebrating Entrepreneurship, Education & Unity within the African-American
Community

DETROIT, June 18 -- "Power in the Black Dollar" was the
theme at the 2008 International Detroit Black Expo, (IDBE), Buy Black
Weekend II, and with it brought a positive influence and harmony that
flowed through downtown Detroit, June 6 - 8. From the educational
experience to the entertainment highlights, the expo was an exciting,
powerful event that included something for everyone.

Opening each day with a vivid exhibit hall that featured over 500
black-owned businesses, the crowd of an estimated 52,000 was witness to the
largest African-American consumer expo in the country. On Friday, Mayor
Kwame Kilpatrick gave welcome and throughout the weekend there were
numerous seminars from various national dignitaries, including Dr. Dennis
Kimbro, Dr. Jawanza Kunjufu and Dr. Leonard Jefferies.

Not only was there excitement during the day from the exhibits, over
100 workshops and speakers, but festivities also continued after-hours with
entertainment and parties. The Black Awards Gala at the Sheraton featured
dinner, live music and a surprise celebrity appearance from Ernest Thomas,
"Raj" from the hit sitcom, "What's Happening." On Sunday night, the crowd
gathered at the finale as John Salley headlined the party at Amnesia inside
Motor City Casino with the Paul Jenkins Jr. Foundation.

With a 1.8 million dollar economic impact, Buy Black Weekend II was a
huge success in providing resources, education and networking
opportunities. "We are extremely excited to have hosted the 2nd Annual Buy
Black Weekend," said Ken Harris, IDBE Founder & CEO. "The 2009
International Detroit Black Expo, June 5 - 7, will surely be just as
impactful and substantive for all aspiring entrepreneurs and businesses
looking to compete in the global economy."

Please contact the IDBE office at (313) 309-3215 or
http://www.DetroitBlackExpo.com for more details, to obtain vendor, sponsorship
and/or media information.

The International Detroit Black Expo, Inc (IDBE), is a 501 (c)(3)
tax-exempt not-for-profit organization, whose mission is to cultivate
prosperity among African-American businesses and organizations through
cultural, entrepreneurial, social, educational and business opportunities
that will further enhance the quality of life for the City of Detroit and
surrounding communities, while bridging those who choose access to the
global marketplace.




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Ulrich Schnauss

   
Artist: Ulrich Schnauss

   Genre(s): 
Electronic
   Dance
   Other
   Ambient
   

---

Discography:


   
 Quicksand Memory Ep

   Year: 2007   
Tracks: 4


   
 Goodbye

   Year: 2007   
Tracks: 10


   
 Remixcollection

   Year: 2004   
Tracks: 18


   
 A Strangely Isolated Place

   Year: 2004   
Tracks: 8


   
 Far Away Trains Passing By

   Year: 2001   
Tracks: 6

---

A more or less secret producer from Berlin, Germany, Ulrich Schnauss debuted under his have discover in 2001 with Far Away Trains Passing By. Released by City Centre Offices, the album ostensibly came from nowhere and wound up on several journalists' year-end favorites lists, impressing many with a beguiling story of charm that referenced the shimmer of the Cocteau Twins and the ticktack mining of the Black Dog. A Strangely Isolated Place followed in 2003, which was much closer to shoegaze than U.K. techno. Schnauss has besides had his work force in a number of other projects, including Hexaquart (minimal techno-house) and Ethereal 77 (drum'n'bass), in addition to technology work for a number of other artists.

Terminator - Special-effects Wizard Winston Dies At 62

Stan Winston, the special-effects wizard, whose work was seen in such films as The
Terminator, Jurassic Park, Aliens, Edward Scissorhands, Batman Returns, and,
most recently, Iron Man, died Sunday of multiple myeloma at age 62 at his
home in Malibu, CA, his company, Stan Winston Studio, said Monday. In a statement,
Steven Spielberg said, "My world would not have been the same without Stan. What
I will miss most is his easy laugh every time he said to me, 'Nothing is impossible.'"




17/06/2008

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R Kelly acquitted

It took six years to bring him to trial but less than 24 hours for a jury to find R Kelly not guilty of having sex with an underage girl. The Grammy award-winning singer dabbed tears from his eyes and thanked Jesus as he was cleared of all 14 counts relating to child pornography at Cook County court in Chicago on Friday. The charges related to a video that prosecutors alleged showed Kelly, now 41, engaging in numerous sex acts with an underage girl. Both the singer and the unnamed girl, who is now 23, deny their involvement.

One of the prosecution witnesses who claimed she had had a three-way sexual encounter with Kelly and the girl in question was labelled an extortionist by the defence, who claimed she sought money from Kelly in exchange for her silence. The prosecution also claimed it was a near impossibility that the tape had been tampered with, while the defence showed the jury their own version of the tape in question after they had doctored it in an attempt to bring the authenticity of the tape into question.

In the end, it appeared to come down to whether the jury was convinced it was the underage girl who appeared in the video. One juror told reporters: "You want to be 100% sure it's Kelly and (the alleged victim). What we had wasn't enough." Another said: "All of us felt very much the grayness of this case." Associated Press report that a vote taken just a few hours before the acquittal had seven jurors voting not guilty and five voting guilty. None of the five jurors who spoke to reporters after the verdict wanted to be identified. The singer would have faced a jail sentence of up to 15 years if found guilty.

Following his acquittal, a spokesman for the singer released a statement saying: "When all the facts came out in court, he would be cleared of these terrible charges. All he wants to do is move forward and put it behind him."

R Kelly is due to release a new album in July.


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